President Franklin D. Roosevelt led the United States through some of the most tumultuous periods in the nation’s history, including the Great Depression and the Second World War. He was also the first known President to have a significant physical disability. Despite those challenges, he implemented some of the most lasting labor reforms in U.S. history and helped ensure the Allied forces’ victory over the Nazis. His bracing wisdom continues to echo down the ages: We can take our doubts into account when making decisions, but we shouldn’t let them hold us back from moving toward our goals.